Clinical Impact

Trusted by Innovators.
Proven in the Field.

These represent just a portion of the trials we've led and delivered.

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Neurology - Stroke
BrainsGate Published
ImpACT-24B Trial
The Lancet · 2019 · PMID 31133406
Sphenopalatine ganglion (SPG) electrical stimulation for acute ischemic stroke. International, randomized, double-blind, sham-controlled pivotal trial. 1,078 patients enrolled across 73 centers.
Pivotal Trial Read Publication
BrainsGate Published
ImpACT-24M Trial
Stroke · 2019 · PMID 31739771
Refined SPG stimulation for acute ischemic stroke using real-time optical electrode guidance. Prospective, single-arm, open-label study. 50 patients enrolled across 4 centers.
Pivotal Trial Read Publication
Ophthalmology - Glaucoma
BELKIN Vision Published
GLAUrious Pivotal Trial
Ophthalmology · 2025 · PMID 40350086
Direct selective laser trabeculoplasty (DSLT) vs. conventional SLT for open-angle glaucoma and ocular hypertension. Prospective, multicenter, randomized, controlled, evaluator-masked noninferiority trial. 192 patients across 14 centers.
Pivotal Trial Read Publication
BELKIN Vision Published
GLAUrious Trial Design Paper
BMJ Open Ophthalmology · 2021 / 2023 · PMID 34433548
Protocol and design paper for the GLAUrious RCT comparing BELKIN's Eagle DSLT device against standard SLT. Randomized, controlled, investigator-masked noninferiority design targeting 164 participants.
Design Paper Read Publication
Cardiology
Vectorious Published
VECTOR-HF I & IIa
European Journal of Heart Failure · 2024
Physician-directed patient self-management of heart failure using the V-LAP implantable left atrial pressure monitoring system. Prospective, single-arm, open-label studies. 13 patients enrolled.
Heart Failure · Device Read Publication
Valcare Medical Published
AMEND FIH Cohort
JACC: Cardiovascular Interventions · 2025
Transseptal transcatheter mitral annuloplasty with the Valcare AMEND system. First-in-human cohort reporting 30-day outcomes of a complete semirigid D-shaped ring for mitral regurgitation.
Mitral Valve · FIH Read Publication
Cell Therapy - Critical Limb Ischaemia
BioGenCell Active Trial
ENEPC-CLI-01 Phase 1/2
Cytotherapy · 2025 · NCT02805023
Autologous enriched endothelial progenitor cell therapy (BGC101) for critical limb ischemia. Phase 1/2, randomized, double-blind, placebo-controlled trial with 2:1 allocation.
Phase 1/2 · Advanced Therapy Read Abstract
Critical Care - ICU
Queen's University / Canadian Critical Care Trials Group Published
FAST-1 Trial
Critical Care Explorations · 2024 · PMID 38511126
Nebulized furosemide for COVID-19 respiratory failure. Phase 2, double-blind, randomised, placebo-controlled RCT. 40 patients enrolled across 7 sites.
Phase 2 RCT Read Publication

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